Chse 235         Efosa Asemota Drug report #2         Cytotec/ Misoprosto Therapeutic category Mucosal prophylactic gent         Use/ indicator For the discourse and lawful profession of NSAID-induced gastroduodenal ulcers. Also indicated for the treatment of duodenal ulcers caused by peptic ulcer Disease (PUD). Adverse reaction The nigh frequent gastrointestinal ominous events were profligacy (10.7%), abdominal throe (7.3%), nausea (4.2%), flatulence (3.3%), and upset stomach (3.2%). The relative incidence of profligacy was 7.8% when the total daily venereal disease was cd & small;g. In patients receiving placebo, the incidence of diarrhea was 3.6%. The events were commonly transient and piano to leave in severity. Contraindication/overdose Possible clinical signs that whitethorn indicate an overdose whitethorn include: sedation, tremor, fever, convulsions, dyspnea, abdominal pain, diarrhea, palpitations, hypotension or bradycardia. Treatment should be diagnostic and supportive. Children: Safety and effectiveness in patients below the jump on of 18 have non been established. Known sensitivity to prostaglandins, prostaglandin analogues or excipients (microcrystalline and hydroxypropyl methylcellulose, sodium starch glycolate and hydrogenated stovepipe oil). Contraindicated in pregnancy.
Initial dosage The recommended adult ad-lib exam dosage for the stripe and treatment of NSAID-induced gastroduodenal ulcer is 400 to 800 µg a day in split up doses. NSAIDs should be taken correspond to the schedule prescribed by the physician. When appropriate, misoprostol and NSAIDs atomic number 18 to be taken simultaneously. Misoprostol should be taken after food. Reference:www.drugs.com, www.pharmclips.com, hypertext rapture protocol://www.rxmed.com,http://www.rxmed.com/b.main/b2.pharmaceutical/b2.prescribe.html If you want to let down a full essay, target it on our website:
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